PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4096)
Related Products (4096)
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PROTAC Linkers Isoform Comparison
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tert-Butyl (trans-3-aminocyclobutyl)carbamate
0 ImagesCat. No.: HY-WAA0308CAS No.: 871014-19-6
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Boc-bipiperidine-NH2
0 ImagesCat. No.: HY-W043245CAS No.: 959237-16-2
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Boc-10-Aminodecanoic acid
0 ImagesCat. No.: HY-W089232CAS No.: 173606-50-3Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W077402CAS No.: 655225-02-8
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4-(2-Boc-aminoethyl)piperidine
0 ImagesCat. No.: HY-40336CAS No.: 165528-81-4
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3-Aminobicyclo[1.1.1]pentan-1-ol hydrochloride
![3-Aminobicyclo[1.1.1]pentan-1-ol hydrochloride](https://file.medchemexpress.com/product_pic/hy-w059687.gif "Click to View 3-Aminobicyclo[1.1.1]pentan-1-ol hydrochloride Product Detail")
0 ImagesCat. No.: HY-W059687CAS No.: 2007921-20-0
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9-(Boc-amino)nonanoic acid
0 Images9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. 9-(Boc-amino)nonanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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tert-Butyl cis-4-(methylamino)cyclohexyl)carbamate
0 ImagesCat. No.: HY-W057911CAS No.: 883864-61-7
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2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.5]nonane-7-carboxylic acid
![2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.5]nonane-7-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w060248.gif "Click to View 2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.5]nonane-7-carboxylic acid Product Detail")
0 ImagesCat. No.: HY-W060248CAS No.: 1363381-18-3
![tert-Butyl (3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-w000137.gif "Click to View tert-Butyl (3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)carbamate Product Detail")
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Di(N-succinimidyl)adipate
0 ImagesCat. No.: HY-141099CAS No.: 59156-70-6
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Azido-PEG6-azide
0 ImagesCat. No.: HY-133393CAS No.: 1243536-56-2Azido-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
